Two Cups Of Coffee A Day Reduces Liver Cancer Risk

Drinking more coffee could reduce the risk of developing the most common form of primary liver cancer, according to a study led by the University of Southampton.

Credit: southampton.ac.uk

Researchers from Southampton and the University of Edinburgh found that the more coffee consumed the greater the protection against hepatocellular cancer (HCC).

Drinking one cup more of caffeinated coffee a day was associated with a 20 per cent reduction in the risk of developing HCC, two cups more with a 35 per cent reduction, and up to five cups with a halving of the risk.

The protection was found to be the same for both existing coffee-drinkers and those who didn’t usually drink it, and the more coffee consumed the greater the effect – although there was little data available above five cups a day.

The research, published in the journal BMJ Open, examined the data from 26 observational studies, involving more than 2.25 million participants, to calculate the relative risks of developing HCC for drinking between one and five cups of caffeinated coffee a day.

Lead author Dr Oliver Kennedy, of the University of Southampton, said: “Coffee is widely believed to possess a range of health benefits, and these latest findings suggest it could have a significant effect on liver cancer risk.

There needs to be more investigation into the potential harms of high coffee-caffeine intake, and there is evidence it should be avoided in certain groups such as pregnant women.

HCC is the second leading cause of cancer death globally because of its poor prognosis and high frequency, especially in China and Southeast Asia. It mostly develops in people who are already suffering from chronic liver disease.

It is estimated that, by 2030, the number of new cases annually will have risen by about 50 per cent to more than 1.2 million.

The compound molecules found in coffee possess antioxidant, anti-inflammatory, anticarcinogenic and other beneficial properties which scientists believe may explain the lower rates of chronic liver disease and liver cancer experienced by coffee-drinkers.

About 2.25 billion cups of coffee are consumed daily worldwide, and increased coffee consumption has already been shown to protect against serious non-cancer chronic liver disease (cirrhosis).

Source - scind.org

NO TOBACCO DAY - 31 May

Please circulate this poster and the above message (you can edit if you feel) to all your whatsapp groups & contacts and them to further forward the same to their groups and contacts.

First Human Antibodies To Work Against All Ebolaviruses

Credit-CDC.org

After analyzing the blood of a survivor of the 2013-16 Ebola outbreak, a team of scientists from academia, industry and the government has discovered the first natural human antibodies that can neutralize and protect animals against all three major disease-causing ebolaviruses. The findings, published online in the journal Cell, could lead to the first broadly effective ebolavirus therapies and vaccines.

Ebolaviruses infections are usually severe, and often fatal. There are no vaccines or treatments approved by the Food and Drug Administration for treating these viruses. Some two dozen ebolavirus outbreaks have occurred since 1976, when the first outbreak was documented in villages along the Ebola River in the Democratic Republic of Congo (formerly Zaire). The largest outbreak in history - the 2013-16 Western African epidemic - caused more than 11,000 deaths and infected more than 29,000 people.

Monoclonal antibodies, which bind to and neutralize specific pathogens and toxins, have emerged as one of the most promising treatments for Ebola patients. A critical problem, however, is that most antibody therapies target just one specific ebolavirus. For example, the most advanced therapy- ZMappTM, a cocktail of three monoclonal antibodies - is specific for Ebola virus (formerly known as "Ebola Zaire"), but doesn't work against two related ebolaviruses (Sudan virus and Bundibugyo virus) that have also caused major outbreaks.

In earlier research, Dr. Bornholdt and Laura M. Walker, Ph.D., a senior scientist at Adimab, LLC, isolated 349 distinct monoclonal antibodies from a survivor of the 2013-16 Ebola epidemic. In the current study, the multi-institutional research team found that two of those 349 antibodies, known as ADI-15878 and ADI-15742, potently neutralized infection by all five known ebolaviruses in tissue culture. Both antibodies were able to protect animals (mice and ferrets) that had been exposed to a lethal dose of the three major agents: Ebola virus, Bundibugyo virus and Sudan virus.

Follow-up studies showed that the two antibodies isolated from the Ebola patient work by interfering with a critical step in the process by which ebolaviruses infect cells and then multiply inside them. The two antibodies encounter the virus while it's still in the bloodstream, and bind to glycoproteins (proteins to which carbohydrate chains are attached) that project from its surface. The virus, with its hitchhiking antibodies still bound to it, then attaches to a cell and enters the lysosome - a membrane-bound structure within the cell that is filled with enzymes for digesting foreign and cellular components. The virus must then fuse with the lysosome membrane to escape into the host cell's cytoplasm, where it can multiply. However, the antibodies prevent the virus from breaking out of its lysosomal "prison," thus stopping infection in its tracks.

Source - scind.org

खिलौने - आपके बच्चों को अस्वस्थ बना सकते है।

दोस्तों, 

खिलौने किसे पसंद नहीं है, बच्चो के साथ साथ बड़े भी  इसका लुत्फ़ उठाते है।  बच्चों  के खिलौने एक ऐसी चीज है जिनसे वह कुछ न कुछ सीखते है, पहले लकड़ी के खिलौनों का काफी चलन था, पर समय के साथ- साथ प्लास्टिक का भी इस्तेमाल खिलौनों को बनाने में होने लगा है, आजकल इसका भारतीय बाजार करीब करीब 400 मिलियन डॉलर का है, खैर बाजार का हमें ज्यादा कुछ करना नहीं है, खास बात यह है की कंपनिया (सस्ते खिलौने बनाने वाली) या पडोसी देश जिनसे हम यह खिलौनों को आयात करते है वह लोग सस्ते प्लास्टिक का इस्तेमाल कर रहे है।  शायद नए प्लास्टिक को खरीदना महंगा हो सकता इसीलिए वो सस्ता प्लास्टिक खरीदते है, लेकिन उस सस्ते प्लास्टिक में कुछ रीसाइकल्ड प्लास्टिक भी हो सकता है, और प्लास्टिक में हानिकारक रसायन मिला हुआ प्लास्टिक भी होने की सम्भावना हो सकती है जैसे की इलेक्ट्रॉनिक कचरे से आया हुआ प्लास्टिक (इलेक्ट्रॉनिक चीजे बनाते वक़्त उन्हें शॉट सर्किट से एकदम से आग न लगे इसलिए BFR नामक रसायन मिलाया जाता है, BFR - Brominated  Flame Retardant), यह रसायन हमारे लिए और पर्यावरण के लिए हानिकारक है।  

अभी कुछ समय पहले एक अंतर्राष्ट्रीय अध्ययन किया गया जिसमे हमारे देश से भी कुछ सैम्पल्स भेजे गए थे, उसमे BFR रसायन के कुछ अंश पाए गए। इससे यही अनुमान लगाया जा सकता है की वह खिलौनों  बनाते वक़्त ऎसे प्लास्टिक का इस्तेमाल किया गया जिसमे BFR पहले से मौजूद था याने की वह प्लास्टिक सही नहीं था, इलेक्ट्रॉनिक कचरे से रीसाइकल्ड किया भी होने की आशंका है। 

अगर ऐसे रसायन भरे खिलौनों  हम अपने बच्चों को दे रहे है तो हम उन्हें उन्हें एक प्रकार से जेहरीले खिलोने दे रहे है, बच्चों की यह आदत भी होती है की वो उसे मुँह में भी डालते है जिससे की खिलौने में घुले रसायन उनके शरीर में जाकर उन्हें अस्वस्थ बना सकते है।  ऐसे खिलौनों को खरीदने से हमे बचना चाहिए।  

उन्ही खिलौनों  को चुनिए जो नियमो के तहत बनाये गए है और जिसमे यह भी लिखा हो की यह बच्चों के लिए सुरक्षित है। 

हमारी यह समझदारी अपने बच्चों को स्वस्थ रख सकती है। 

निचे दी गयी लिंक पे आप Zee News की विस्तृत खबर देख सकते है। 

Zee News

आपका दोस्त 

डा प्रशांत राजनकर 

9650745900